Immunoglobulin G Subclass 2 Unit Converter

Immunoglobulin G Subclass 2 (IgG2) is one of four subtypes of IgG, the most abundant antibody class in human blood. IgG2 makes up roughly 32% of total IgG and plays a specialized role in the immune system's defense against bacteria that have polysaccharide (sugar-based) capsules.

When the body encounters encapsulated bacteria such as Streptococcus pneumoniae or Haemophilus influenzae type b, the antibody response is almost entirely restricted to the IgG2 subclass. This makes IgG2 uniquely important for protection against these common pathogens.

IgG2 has a half-life of about 21 days and is measured alongside the other IgG subclasses (IgG1, IgG3, IgG4) when investigating suspected antibody deficiency or recurrent infections.

IgG2 is produced by plasma cells, which are mature B lymphocytes found in the bone marrow, spleen, lymph nodes, and mucosal tissues. B cells undergo class switching to produce IgG2 primarily in response to T-independent polysaccharide antigens.