Total Cortisone, Urine Creatinine Ratio Unit Converter

Total cortisone (urine, creatinine ratio) measures the amount of cortisone excreted in your urine, adjusted for urine concentration using creatinine. Cortisone is the inactive form of cortisol, your body's primary stress hormone.

Your body converts active cortisol into inactive cortisone primarily through an enzyme called 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), found mainly in the kidneys. This conversion serves as a protective mechanism, preventing cortisol from overstimulating mineralocorticoid receptors.

Dividing by creatinine corrects for how dilute or concentrated the urine sample is, making results comparable across different collections and hydration levels.

Cortisone is produced when the enzyme 11β-HSD2 converts active cortisol to inactive cortisone, primarily in the kidneys, colon, and salivary glands. The reverse conversion (cortisone back to cortisol) occurs mainly in the liver and fat tissue via the 11β-HSD1 enzyme.