20a-Dihydroprogesterone, Urine Creatinine Ratio Unit Converter

20a-dihydroprogesterone (20α-DHP) is a naturally occurring metabolite of progesterone. It is formed when the enzyme 20α-hydroxysteroid dehydrogenase (20α-HSD) converts progesterone into a less active form.

20α-DHP has roughly one-fifth the progestogenic activity of progesterone itself. Measuring it in urine, normalized to creatinine, provides insight into how efficiently the body is metabolizing and clearing progesterone.

This marker is typically assessed as part of a comprehensive dried urine hormone panel alongside other progesterone metabolites such as pregnanediol and allopregnanediol.

20α-DHP is produced when progesterone is converted by the enzyme 20α-HSD (encoded by the AKR1C1 gene), which is active primarily in the liver, endometrium, mammary gland, ovaries, and central nervous system.